In Disney Villainous: Perfectly Wretched, each player takes control of one of three Disney characters, each one a villain in a different Disney movie, specifically Cruella de Vil from 101 Dalmatians, Mother Gothel from Tangled, and Pete from Steamboat Willie. Each player has their own villain deck, fate deck, player board, and 3D character.

Disney Villainous: Perfectly Wretched is playable on its own, and its characters can also face off against those in the Disney Villainous base game from 2018 and the Disney Villainous: Wicked to the Core and Disney Villainous: Evil Comes Prepared standalone games in 2019.