Throughout the campaign, players make permanent changes to their demigods by collecting powerful artifacts, forging their dice by altering their faces, and earning titles for the feats they achieve. Players will also permanently change the game world by altering tiles and placing new locations, heroes, and monsters onto the map tiles. When players complete quests or other significant goals, they can make pivotal decisions through the Divinus app.

Players will decide the outcome of dilemmas such as choosing which side is victorious in battle, building or destroying a holy site, and choosing whether a God lives or dies. Whichever outcome the player chooses, the game components may be changed and the Divinus app will remember and present contextual options in the future that are impacted by the decision. Returning to a fort that you helped the Norse Gods build could see you praised, while demigods favored by the Greek pantheon could be shunned.

The Divinus campaign is ideally played over several game sessions due to the persistent and changing world. The rulebook grows with each scenario as new rules and content are unlocked. Once the campaign is complete, players can replay their unique copy of Divinus with a post-campaign Infinite Replayability mode.