At the start of the game, each pla yer holds three cards and on a turn a player draws one card, then plays one card. By playing cards, you can put new rules into play that change numerous aspects of the game: how many cards to draw or play, how many cards you can hold in hand or keep on the table in front of you, and (most importantly) how to win the game.

Doctor Who Fluxx takes the basic gameplay of Fluxx and merges it with multiple regenerations of the Doctor, various companions, Gallifreyan technology, K-9, Cybermen, Daleks, Weeping Angels, and the Master.